{"id":38374,"date":"2026-06-14T16:33:55","date_gmt":"2026-06-14T09:33:55","guid":{"rendered":"https:\/\/genesisfertility.co.th\/?p=38374"},"modified":"2026-06-14T16:37:22","modified_gmt":"2026-06-14T09:37:22","slug":"what-is-ngs-in-pgt-a-the-technology-behind-embryo-chromosome-testing","status":"publish","type":"post","link":"https:\/\/genesisfertility.co.th\/en\/what-is-ngs-in-pgt-a-the-technology-behind-embryo-chromosome-testing\/","title":{"rendered":"What Is NGS in PGT-A? \u2014 The Technology Behind Embryo Chromosome Testing"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><em>Reviewed by the Genesis Fertility Center (GFC) medical team \u2014 Last updated June 2026<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">In embryo chromosome screening (PGT-A), the term &#8220;NGS&#8221; comes up frequently. Many people wonder what NGS is and why it matters for testing accuracy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This article explains NGS clearly, so you understand the technology behind embryo testing.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">What Is NGS?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">NGS (Next Generation Sequencing) is a modern, high-accuracy technology for reading genetic sequences. It can comprehensively examine chromosome number and abnormalities in fine detail.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In IVF, NGS is used in PGT-A to screen whether an embryo has a normal chromosome count (46 chromosomes).<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">How NGS Works in PGT-A<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Embryo culture<\/strong> to the Blastocyst stage (day 5-6)<\/li>\n\n\n\n<li><strong>Biopsy<\/strong> of a small sample from the part that will become the placenta (Trophectoderm)<\/li>\n\n\n\n<li><strong>Genetic extraction<\/strong> from the sampled cells<\/li>\n\n\n\n<li><strong>Sequencing with NGS<\/strong> \u2014 analyzing all 23 chromosome pairs<\/li>\n\n\n\n<li><strong>Reporting<\/strong> \u2014 identifying whether each embryo is chromosomally normal or abnormal<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">At GFC, PGT-A using NGS has 99% accuracy with results within 24 hours.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">How NGS Compares to Older Technologies<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Before NGS, several embryo chromosome testing technologies existed, such as FISH and aCGH. NGS offers clear advantages:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th><\/th><th>Older Technology<\/th><th>NGS<\/th><\/tr><\/thead><tbody><tr><td>Accuracy<\/td><td>Moderate<\/td><td>Very high (99%)<\/td><\/tr><tr><td>All 24 chromosome types<\/td><td>Not always complete<\/td><td>\u2705 Complete<\/td><\/tr><tr><td>Detecting small abnormalities<\/td><td>Limited<\/td><td>\u2705 More detailed<\/td><\/tr><tr><td>Speed of results<\/td><td>Slower<\/td><td>\u2705 Fast (24 hrs at GFC)<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">Why NGS Matters for ICSI Success<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">NGS accuracy allows doctors to confidently select chromosomally normal embryos, resulting in:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Higher implantation success rates<\/li>\n\n\n\n<li>Reduced miscarriage risk from chromosomal abnormalities<\/li>\n\n\n\n<li>Fewer unnecessary transfer cycles<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">At GFC, combining ICSI with PGT-A using NGS raises the success rate from 60-65% to 70-75%.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">What NGS Can Detect<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">NGS in PGT-A focuses on <strong>chromosome number<\/strong> (Aneuploidy), such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Whether an embryo has extra or missing chromosomes<\/li>\n\n\n\n<li>Down syndrome risk (extra chromosome 21)<\/li>\n\n\n\n<li>Sex chromosome abnormalities<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">For testing specific genetic diseases (PGT-M), that&#8217;s a different type of test \u2014 consult your doctor directly.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">FAQ<\/h2>\n\n\n<div id=\"rank-math-faq\" class=\"rank-math-block\">\n<div class=\"rank-math-list \">\n<div id=\"faq-question-1781429711540\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \"><strong>Are NGS and PGT-A the same thing?<\/strong> <\/h3>\n<div class=\"rank-math-answer \">\n\n<p>No. PGT-A is the name of the embryo chromosome screening test, while NGS is the technology used to perform it. Simply put, NGS is the tool used to do PGT-A.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1781429726594\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \"><strong>How accurate is NGS?<\/strong> <\/h3>\n<div class=\"rank-math-answer \">\n\n<p>At GFC, NGS testing has 99% accuracy.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1781429733002\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \"><strong>How long do NGS results take?<\/strong> <\/h3>\n<div class=\"rank-math-answer \">\n\n<p> At GFC, results are available within 24 hours.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1781429745215\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \"><strong>Does NGS testing require freezing embryos?<\/strong><\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Yes. After biopsy for NGS, embryos are frozen and then transferred in an FET cycle once results are known.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1781429754273\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \"><strong>Can NGS determine embryo sex?<\/strong><\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Technically NGS can identify sex chromosomes, but selecting embryo sex for non-medical reasons is not permitted under Thai law.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1781429770501\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \"><strong>How much does NGS\/PGT-A cost at GFC?<\/strong><\/h3>\n<div class=\"rank-math-answer \">\n\n<p>PGT-A with NGS costs 37,900 THB at GFC.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1781429779775\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \"><strong>Where can I consult about PGT-A?<\/strong> <\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Line @gfcclinic or call 097-484-5335<\/p>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">Summary<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">NGS (Next Generation Sequencing) is a modern genetic sequencing technology used in PGT-A to screen embryo chromosomes with 99% accuracy. It helps select chromosomally normal embryos, increasing success rates and reducing miscarriage risk.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">At GFC, PGT-A with NGS costs 37,900 THB with results in 24 hours.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2192 Learn more about PGT-A \u2192 <a href=\"\/en\/pgta-embryo-screening-success-rate\/\">PGT-A Explained<\/a> \u2192 See ICSI services \u2192 <a href=\"\/en\/services\/services-ivf-icsi-treatment\/\">ICSI at GFC<\/a> \u2192 <a href=\"\/en\/contact\/\">Book a Free Consultation<\/a> or Line @gfcclinic | Tel: 097-484-5335<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Reviewed by the Genesis Fertility Center (GFC) medical team \u2014 Last updated June 2026 In&hellip;<\/p>\n","protected":false},"author":22,"featured_media":32005,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[448],"tags":[],"class_list":["post-38374","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/genesisfertility.co.th\/en\/wp-json\/wp\/v2\/posts\/38374","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genesisfertility.co.th\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/genesisfertility.co.th\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/genesisfertility.co.th\/en\/wp-json\/wp\/v2\/users\/22"}],"replies":[{"embeddable":true,"href":"https:\/\/genesisfertility.co.th\/en\/wp-json\/wp\/v2\/comments?post=38374"}],"version-history":[{"count":1,"href":"https:\/\/genesisfertility.co.th\/en\/wp-json\/wp\/v2\/posts\/38374\/revisions"}],"predecessor-version":[{"id":38375,"href":"https:\/\/genesisfertility.co.th\/en\/wp-json\/wp\/v2\/posts\/38374\/revisions\/38375"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/genesisfertility.co.th\/en\/wp-json\/wp\/v2\/media\/32005"}],"wp:attachment":[{"href":"https:\/\/genesisfertility.co.th\/en\/wp-json\/wp\/v2\/media?parent=38374"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/genesisfertility.co.th\/en\/wp-json\/wp\/v2\/categories?post=38374"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/genesisfertility.co.th\/en\/wp-json\/wp\/v2\/tags?post=38374"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}